Effect of cholecystokinin-8 microinjection into ventral tegmental area on dopamine release in nucleus accumbens of rats: An in vivo voltammetric study
Identifieur interne : 003333 ( Main/Exploration ); précédent : 003332; suivant : 003334Effect of cholecystokinin-8 microinjection into ventral tegmental area on dopamine release in nucleus accumbens of rats: An in vivo voltammetric study
Auteurs : Jun-Xia Xie [République populaire de Chine] ; MING TANG [République populaire de Chine] ; CHUNYI ZHANG [Canada]Source :
- Progress in neuro-psychopharmacology & biological psychiatry [ 0278-5846 ] ; 2001.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
1. Effects of microinjection of cholecystokinin-8 (CCK-8) into the rat ventral tegmental area were studied on dopamine (DA) release from nucleus accumbens (Acb), using fast cyclic voltammetry and carbon fibre microelectrode. 2. DA release was evoked by electrical stimulation of the medial forebrain bundle (MFB). DA release from Acb was increased with increasing intensity or frequency of electrical stimulation in a dose-dependent manner and was inhibited by microinjection of CCK-8 (0.5 μg/kg) into the ventral tegmental area. 3. The release of DA was clearly reduced at all the intensities (0.25, 0.5, 0.75 and 1.0mA) tested following CCK injection into the VTA, which was statistically significant (P<0.05). But the reduced percentage of DA release did not show significant changes between the data obtained with stimuli of different intensities (P>0.05). 4. While no change could be found with the stimuli of 10Hz, the DA release was significantly suppressed by injection of CCK-8 at the other three frequencies tested (50Hz, 100Hz and 250Hz). Furthermore, although the differences in the reduced amounts of DA release obtained at 50 Hz, 100 Hz and 250 Hz were statistically significant, the reduced percentage seemed to be not closely related to the frequency applied (P>0.05). 5. These results indicate that CCK-8 is involved in the regulation of midbrain DA neurotransmission, and thereby implicated in disorders, such as Parkinson's disease, that involve malfunctions of the basal ganglion DA neuronal systems.
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Chine</country><wicri:noRegion>Qingdao</wicri:noRegion></affiliation></author><author><name sortKey="Chunyi Zhang" sort="Chunyi Zhang" uniqKey="Chunyi Zhang" last="Chunyi Zhang">CHUNYI ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute for Biological Sciences, NRC</s1><s2>Ottawa, Ontario</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">01-0215355</idno><date when="2001">2001</date><idno type="stanalyst">PASCAL 01-0215355 INIST</idno><idno type="RBID">Pascal:01-0215355</idno><idno type="wicri:Area/PascalFrancis/Corpus">000C34</idno><idno type="wicri:Area/PascalFrancis/Curation">000089</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B14</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000B14</idno><idno type="wicri:doubleKey">0278-5846:2001:Xie J:effect:of:cholecystokinin</idno><idno type="wicri:Area/Main/Merge">003821</idno><idno type="wicri:Area/Main/Curation">003333</idno><idno type="wicri:Area/Main/Exploration">003333</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effect of cholecystokinin-8 microinjection into ventral tegmental area on dopamine release in nucleus accumbens of rats: An in vivo voltammetric study</title><author><name sortKey="Xie, Jun Xia" sort="Xie, Jun Xia" uniqKey="Xie J" first="Jun-Xia" last="Xie">Jun-Xia Xie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Medical College of Qingdao University</s1><s2>Qingdao</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Qingdao</wicri:noRegion></affiliation></author><author><name sortKey="Ming Tang" sort="Ming Tang" uniqKey="Ming Tang" last="Ming Tang">MING TANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, Medical College of Qingdao University</s1><s2>Qingdao</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Qingdao</wicri:noRegion></affiliation></author><author><name sortKey="Chunyi Zhang" sort="Chunyi Zhang" uniqKey="Chunyi Zhang" last="Chunyi Zhang">CHUNYI ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute for Biological Sciences, NRC</s1><s2>Ottawa, Ontario</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Progress in neuro-psychopharmacology & biological psychiatry</title><title level="j" type="abbreviated">Prog. neuro-psychopharmacol. biol. psychiatr.</title><idno type="ISSN">0278-5846</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Progress in neuro-psychopharmacology & biological psychiatry</title><title level="j" type="abbreviated">Prog. neuro-psychopharmacol. biol. psychiatr.</title><idno type="ISSN">0278-5846</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Brain (vertebrata)</term><term>Central nervous system</term><term>Cholecystokinin</term><term>Dopamine</term><term>Dopaminergic transmission</term><term>Dose activity relation</term><term>Electrical stimulus</term><term>Intracerebral administration</term><term>Nucleus accumbens</term><term>Rat</term><term>Ventral tegmental area</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cholécystokinine</term><term>Stimulus électrique</term><term>Transmission dopaminergique</term><term>Dopamine</term><term>Aire tegmentaire ventrale</term><term>Noyau accumbens</term><term>Encéphale</term><term>Système nerveux central</term><term>Animal</term><term>Rat</term><term>Voie intracérébrale</term><term>Relation dose réponse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. Effects of microinjection of cholecystokinin-8 (CCK-8) into the rat ventral tegmental area were studied on dopamine (DA) release from nucleus accumbens (Acb), using fast cyclic voltammetry and carbon fibre microelectrode. 2. DA release was evoked by electrical stimulation of the medial forebrain bundle (MFB). DA release from Acb was increased with increasing intensity or frequency of electrical stimulation in a dose-dependent manner and was inhibited by microinjection of CCK-8 (0.5 μg/kg) into the ventral tegmental area. 3. The release of DA was clearly reduced at all the intensities (0.25, 0.5, 0.75 and 1.0mA) tested following CCK injection into the VTA, which was statistically significant (P<0.05). But the reduced percentage of DA release did not show significant changes between the data obtained with stimuli of different intensities (P>0.05). 4. While no change could be found with the stimuli of 10Hz, the DA release was significantly suppressed by injection of CCK-8 at the other three frequencies tested (50Hz, 100Hz and 250Hz). Furthermore, although the differences in the reduced amounts of DA release obtained at 50 Hz, 100 Hz and 250 Hz were statistically significant, the reduced percentage seemed to be not closely related to the frequency applied (P>0.05). 5. These results indicate that CCK-8 is involved in the regulation of midbrain DA neurotransmission, and thereby implicated in disorders, such as Parkinson's disease, that involve malfunctions of the basal ganglion DA neuronal systems.</div></front></TEI><affiliations><list><country><li>Canada</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xie, Jun Xia" sort="Xie, Jun Xia" uniqKey="Xie J" first="Jun-Xia" last="Xie">Jun-Xia Xie</name></noRegion><name sortKey="Ming Tang" sort="Ming Tang" uniqKey="Ming Tang" last="Ming Tang">MING TANG</name></country><country name="Canada"><noRegion><name sortKey="Chunyi Zhang" sort="Chunyi Zhang" uniqKey="Chunyi Zhang" last="Chunyi Zhang">CHUNYI ZHANG</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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